What is this drug used for?
For the adjunctive treatment of acne vulgaris, flat wart, mucous leukoplakia, pityriasis rubra pilaris, keratosis pilaris, and psoriasis.

How is this drug best apply?

○  Acne vulgaris: apply the medicine gently to the affected area once before bedtime.

○  Psoriasis, ichthyosis, and other rashes: apply the medicine 1-3 times a day or as advised by the doctor.

○  Wash your hands after use.

Warning and Caution!
1. Women with the first trimester of pregnancy are prohibited.
2. Breastfeeding women are prohibited.
3. Do not use this product if you are allergic to any ingredients.
4. Do not apply to mucous, such as eyes, mouth.
5. Eczema, sunburn, acute dermatitis, and rosacea patients should be avoided.
6. This product is preferred used at night and before going to bed. During the treatment, the patient should avoid sun exposure or use shading measures.
7. This product should not be used in a large area; the daily dosage should not exceed 20g.

What do I do if I miss a dose?
If it is closer to the next application time, skip the missed dose, and apply the normal dose at the next normal application time.

What are some adverse reactions that I need to know?

○  This product may cause skin irritation symptoms, such as burning, erythema, and peeling, which may make skin lesions more pronounced, but may also indicate that the drug is working, not exacerbating the condition.

○  Skin mostly can adapt to and tolerate; the irritant phenomenon can disappear gradually if the irritant phenomenon is continued or aggravated, can be used intermittently under doctor guidance, or suspend using.

Storage conditions
Seal and store in a cool (not more than 20℃) place, avoid the light.

Reference:
Tretinoin Cream Package Insert

What is this drug used for?
1. It is used to stop the spread of meningitis in people who carry the bacteria but are not sick with the disease.
2. It is used to treat TB (tuberculosis).
3. It may be given to you for other reasons. Talk to your doctor.

How is this drug best taken?
1. Take on an empty stomach. Take 1 hour before or 2 hours after meals.
2. Do not take antacids within 1 hour of this drug.

Warning and caution！
What should I tell my doctor before taking this medicine?
1. If you have an allergy to rifampin or any other part of this drug.
2. If you are allergic to this drug; any part of this drug; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
3. If you take any drugs (prescription or OTC, natural products, vitamins) that must not be taken with this drug, like certain drugs that are used for HIV, infections, or depression. There are many drugs that must not be taken with this drug. Your doctor or pharmacist can tell you if you are taking a drug that must not be taken with this drug.
4. If you are breast-feeding or plan to breast-feed.
5. This is not a list of all drugs or health problems that interact with this drug.
6. Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this drug with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What do I need to know or do to take this medicine
1. Tell all of your health care providers that you take this drug. This includes your doctors, nurses, pharmacists, and dentists.
2. Have blood work checked as you have been told by the doctor. Talk to the doctor.
3. This drug may affect certain lab tests. Tell all of your health care providers and lab workers that you take this drug.
4. Talk to your doctor before you drink alcohol.
5. If you have high blood sugar (diabetes), you will need to watch your blood sugar closely.
6. A severe and sometimes deadly reaction has happened. Most of the time, this reaction has signs like fever, rash, or swollen glands with problems in body organs like the liver, kidney, blood, heart, muscles, and joints, or lungs. If you have questions, talk to the doctor.
7. If you are 65 or older, use this drug with care. You could have more side effects.
8. Birth control pills and other hormone-based birth control may not work as well to prevent pregnancy. Use some other kind of birth control also like a condom when taking this drug. Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using this drug while you are pregnant.
9. It can cause your urine and sweat to have an orange or reddish color. This is completely harmless –it is nothing for you to worry about.
10. If you wear soft contact lenses please be aware that rifampicin can cause your lenses to become discolored or stained you may want to discuss this with your doctor or optician.

What are some side effects that I need to call my doctor about right away?
1. Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin
2. Signs of kidney problems like unable to pass urine, change in how much urine is passed, blood in the urine, or a big weight gain.
3. Feeling very tired or weak.
4. Feeling confused.
5. Dizziness or passing out.
6. Flu-like signs.
7. Fever or chills.
8. Sore throat.
9. Swollen gland.
10. Joint pain or swelling.
11. Muscle pain or weakness.
12. Shortness of breath.
13. Chest pain.
14. Cough.
15. Sweating a lot.
16. A heartbeat that does not feel normal.
17. Swelling in the arms or legs.
18. Any unexplained bruising or bleeding.
19. Purple spots or redness of the skin.
20. Change in balance.
21. Not able to focus.
22. Period (menstrual) changes.
23. Change in eyesight, eye pain, or very bad eye irritation.
24. Change in tooth color. These changes may be long-lasting.

What do I do if I miss a dose?
All oral products:
1. Take a missed dose as soon as you think about it.
2. If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
3. Do not take 2 doses at the same time or extra doses.

Storage conditions

1. Store at room temperature.
2. Protect from heat and light.
3. Store in a dry place. Do not store in a bathroom.

Reference:
1. Rifampin Capsules Package Insert
2. Applied Pharmaceutical Practice（2009）
3. Up to date

What is this drug used for?
It is used to treat pimples (acne).

How is this drug best taken?
Take with food.

Warning and Caution!
1. Do not take if you are pregnant or if you may get pregnant.
2. Women of child-bearing age or their spouses should take effective contraceptive measures three months before starting treatment, during treatment, and within three months after stopping treatment.
3. Nursing women, severe hepatic, and renal dysfunction, vitamin A excess patients are prohibited.
4. Do not donate blood while using this drug and for three months after stopping.
5. Avoid prolonged exposure to sunlight and UV rays.
6. This product should not be used with supplements containing vitamin A.
7. There may be transient exacerbations of acne symptoms at the beginning of treatment.

What do I do if I miss a dose?
1. If it is closer to the next dose, skip the missed dose and take the regular dose at the next normal time.
2. Do not take two or extra doses at the same time.

What are some side effects that I need to call my doctor about right away?
1. Signs of anaphylaxis, such as rashes, itching, redness, redness, blisters, or peeling of the skin.
2. Signs or symptoms of depression, suicidal thoughts, mood swings, anxiety, or lack of interest in life.
3. Chest pain, difficulty swallowing, severe heartburn, stomach pain, or vomiting.
4. Signs of high blood sugar, such as feeling sleepy, more thirsty and hungry, urinating more frequently, blushing, shortness of breath, or breathing that smells like fruit.
5. Unexplained bruises or bleeding.
6. Heart rate is fast or abnormal.

Storage conditions
1. Seal and store in a cool (not more than 20℃) dry place.
2. Please do not store it in the bathroom.
3. Keep medicines out of reach of children and pets

Reference:
1. Isotretinoin Soft Capsules Package Insert
2. Up to date

What is this drug used for?

• Used for iron-deficiency anemia caused by chronic blood loss, such as bleeding from menstruation, hemorrhoids and uterine fibroids.
• It can also be used for the iron-deficiency anemia caused by malnutrition and maternal iron deficiency anemia.

How is this drug best taken?
Take with or without food. Take with food if it causes an upset stomach.
• Take by mouth only.
• Take 1 to 2 tablets once a day for adults, as prescribed by your doctor.
• Certain foods and medicines can reduce the effectiveness of iron tablets.
• Iron tablets usually should not be taken with food, certain antibiotics, tea, coffee, calcium supplements, or milk. Iron should be taken one hour before or two hours after these items.

• If you take antacids, your iron tablets should be taken two hours before or four hours after the antacids
• Iron tablets are best absorbed in an acidic environment; taking iron with vitamin C tablet or orange juice can enhance iron absorption

What are some side effects of oral iron?
• Some people experience a metallic taste, nausea, constipation, stomach upset, dark-colored stools, and/or vomiting after taking oral iron.
• Options for dealing with these side effects include:

   ○ Take a smaller dose

   ○ Take iron with food (even though this will reduce the amount of iron your body absorbs, it's still better than not taking it at all)

   ○ Switch to injectable iron

• Taking iron tablets will turn the stool a dark, almost black color (actually dark green). This is to be expected and does NOT mean that the iron tablets are causing intestinal bleeding.

What do I do if I miss a dose?
• Take a missed dose as soon as you think about it.

• If it is close to the time for your next dose, skip the missed dose and go back to your normal time.

• Do not take 2 doses at the same time or extra doses.

Storage conditions
1. Store in a cool and dry place (10-30 ℃). Children are at particular risk of iron poisoning, making it very important to store iron tablets out of the reach of children.

Reference:
1. New edition of pharmacology
2. Product package insert
3. Up to date

Step 1: Opening your HANDIHALER device
• Open the dust cap (lid) by pressing the green piercing button.
• Pull the dust cap (lid) upwards away from the base to expose the mouthpiece.
• Open the mouthpiece by pulling the mouthpiece ridge up and away from the base so the center chamber is showing.

Step 2: Inserting the SPIRIVA capsule into your HANDIHALER device
• Each day, separate only 1 of the blisters from the blister card by tearing along the perforated line.
• Remove the SPIRIVA capsule from the blister.
• Place the SPIRIVA capsule in the center chamber of your HANDIHALER device.
• Close the mouthpiece firmly against the gray base until you hear a click. Leave the dust cap (lid) open.

Step 3: Piercing the SPIRIVA capsule
• Hold your HANDIHALER device with the mouthpiece pointed up.
• Press the green piercing button once until it is flat (flush) against the base, then release. This is how you make holes in the SPIRIVA capsule so that you get your medicine when you breathe in.
• Do not press the green button more than one time.
• Do not shake your HANDIHALER device.
• The piercing of the SPIRIVA capsule may produce small gelatin pieces. Some of these small pieces may pass through the screen of your HANDIHALER device into your mouth or throat when you breathe in your medicine. This is normal. The small pieces of gelatin should not harm you.

Step 4: Taking your full daily dose
• Breathe out completely in 1 breath, emptying your lungs of any air.
• Hold your head in an upright position while you are looking straight ahead.
• Raise your HANDIHALER device to your mouth in a horizontal position. Do not block the air intake vents.

• Close your lips tightly around the mouthpiece.
• Breathe in deeply until your lungs are full. You should hear or feel the SPIRIVA capsule vibrate (rattle).
• Hold your breath for a few seconds and, at the same time, take your HANDIHALER device out of your mouth.
• Breathe normally again.
• To get your full daily dose, you must again, breathe out completely and for a second time, breathe in from the same SPIRIVA capsule. (Do not press the green piercing button again.)

Reference: 

SPIRIVA HANDIHALER Package Insert

What is this Lice Shampoo used for?
1. It is used to treat head lice.

How to use Lice Shampoo?
1. Apply adequate lice shampoo on hair then massage until making a rich foam.
2. Wait 5-10 minutes, then rinse.
3. Dry with a clean towel.

Warning and caution！
1. Avoid applying this drug to the eyes or mouth. If this product gets in these areas, rinse with plenty of water.
2. Avoid the use of hair conditioner or shampoo-conditioner combination products before application of the lice shampoo.
3. Use of a nit comb to remove lice and nits after treatment may help to decrease the risk for re-infestation. Nit combing can be performed every two to three days for two to three weeks.
4. Clean clothing should be put on after lice shampoo treatment. Hair should not be rewashed for at least one to two days after the use of the lice shampoo.
5. A few live lice may be seen 8 to 12 hours after using the lice shampoo, and there is no need to immediately reapply the shampoo if they are moving slower than they were prior to treatment.
6. However, if lice are as active as before treatment, the treatment may not be effective.
7. Thus, a second treatment is needed with the lice shampoo 7-9 days after the first treatment.

How to prevent head lice spreading?
1. Wash clothes, bedding, and towels in hot water and dry them on the hottest setting.
2. Vacuum your carpets and furniture.
3. Put things you cannot wash into a sealed plastic bag for 2 weeks.
4. Adults and children who live with a person diagnosed with lice should be examined for lice and treated if needed.
5. Anyone who sleeps in the same bed should be treated for lice, even if no lice or eggs are found.
6. Not sharing a bed, clothes, or personal items with someone who has lice.

Storage conditions
1. Store at room temperature.
2. Protect from light and moisture.
3. Do not store in the bathroom. Keep it away from children and pets.

Reference:
1. Lice Shampoo instructions
2. https://www.webmd.com
3. Up to date

What is this drug used for?
1、 For chronic superficial gastritis associated with helicobacter pylori (Hp) infection.
2、 It is used to relieve stomach pain and heartburn caused by excessive stomach acid.
3、 For gastric and duodenal ulcer to promote the healing of the peptic ulcer.

How is this drug best taken?
1、To be taken by mouth.
2、As prescribed by your doctor. To take half an hour before meals during day time. The evening dose to be taken two hours after dinner.

Warning and caution
1、The product is usually not to be used continuously for more than 7 days
2、Do not take other bismuth preparations while taking this product, and do not use it in large doses for a long time.
3、During treatment with oral bismuth, alcohol, and carbonated drinks are preferably not to be consumed, besides to minimize coffee and tea intake.

Drug-drug interactions
1. Antacids: may interfere with the action of oral bismuth, take at least half an hour apart.
2. Tetracycline: combined use can affect the absorption of tetracycline.

Drug-food interactions
1. A high-protein diet (such as milk) can interfere with the effect of oral bismuth, take at least half an hour apart.

What are some side effects of this drug?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Constipation.
- Dark tongue and stool.
- Ammonia taste in the mouth
- Vomiting, anorexia, diarrhea.

What do I do if I miss a dose?
1. Skip the missed dose and go back to your normal time.
2. Do not take 2 doses at the same time or extra doses.

Storage conditions
1、Keep in a cool and dry place (10-30 ℃)

Reference:
1、Clinical medication guidelines for Chinese physicians and pharmacists (2nd edition)
2、Product package insert

Items from the “Diazepam Rectal Use Kit”：
1. Diazepam injection: 10mg/2ml *1 amp
2. Rectal tube x 1
3. Syringe 5ml x1
4. Lubricating Jelly

Step1: Put person on their side where they can’t fall.

Step 2: Get the “Diazepam Rectal Use Kit”.

Step 3: Gently tap the liquid down if the liquid is at the top of the ampoule. Break the glass ampoule on the blue dot. Use a piece of tissue paper or cloth to protect your thumb.

Step 4: Draw        ml solution (dosage of diazepam 5mg/ml from your doctor) using the syringe and needle from the kit. Remove the needle from syringe, cap and discard the needle.

Step 5: Get the rectal tube. Attach the black part of the tube to the medication-filled syringe. Lubricate the white part of the tube with the lubricating jelly.

Step 6: Turn person on side facing you.

Step 7: Bend upper leg forward to expose rectum. 

Step 8: Separate buttocks to expose rectum.

Step 9: Gently insert white part of the rectal tube at least half length into the rectum with the syringe attached.

Step 10 to Step 13:
10. Slowly count to 3 while gently pushing plunger in until it stops.
11. Slowly count to 3 before removing syringe from rectum.

12. Slowly count to 3 while holding buttocks together to prevent leakage.

13. Keep person on side facing you, note time given and continue to observe.

Note：Discard all used materials in the garbage can. Do not reuse it. Discard in a safe place away from children.

Probiotics are live organisms that provide therapeutic or preventative benefits for the host.

There are more than 20 kinds of probiotics used in China, mainly including bifidobacterium, lactobacillus, clostridium butyricum, saccharomyces boulardii, enterococcus, bacillus licheniformis, and bacillus cereus. Unlike other drug labels, the amount of probiotics is represented by the number of colony-forming units (CFU) in each package, which corresponds to the number of live bacteria. The clinical use of probiotics in JIAHUI hospital is summarized in the attached table.

Recommended common applications of probiotics
1. Acute diarrhea The main treatment principles of acute diarrhea are the prevention and treatment of dehydration continued feeding and rational use of drugs, etc. Probiotics can shorten the course of diarrhea and reduce the length of hospital stay. It is recommended to use bratella yeast powder, bifidobacteria triple viable powder, bifidobacteria quadruplex viable tablet, bacillus subtilis double viable tablet, clostridium caseinate viable powder, clostridium caseate double viable tablet, bacillus licans viable pellets, compound lactic acid bacteria capsule, lactobacillus bifidi triple viable tablet/enteric capsule.

2. Antibiotic-Associated Diarrhea (AAD) The occurrence of AAD is related to the type and course of antibiotics used, the patient's age, length of hospital stay, complications, and other factors. Taking probiotics together with antibiotics can significantly reduce the incidence of AAD and reduce the degree of AAD. It is recommended to use yeast blabella, clostridium tyrosate, bifidobacterium bifidum, lactobacillus bifidum, clostridium tyrosate, bacillus subtilis, and bacillus licheniformis.

3. Treatment of irritable bowel syndrome (IBS) It is recommended to use bifidobacterium treble viable capsules, bacillus subtilis two viable enteric capsules, bifidobacterium four viable tablets and clostridium tyrosinate viable capsules.

4. Treatment of lactose intolerance Probiotics assisted in the treatment of lactose intolerance in infants can significantly shorten the course of treatment and hospital stay. It is recommended to use lactobacillus bifidum triple viable tablet, bacillus subtilis double viable pellets, bifidobacteria triple viable powder, and clostridium caseate double viable powder.

5. Functional constipation Probiotics can improve fecal intestinal transportation time, enhance intestinal movement frequency, significantly improve defecation frequency and fecal viscosity, relieve defecation pain and difficult symptoms, and reduce the recurrence rate of functional constipation. It is recommended to use bifidobacteria triple viable powder/enteric capsule, lactobacillus bifidobacteria triple viable tablet, bacillus subtilis double viable pellets, clostridium tyrosinate double viable powder, bacillus brabella and bacillus licheniformis.

Be paid attention to in the use of probiotics
Probiotics should be taken with cold, warm water or milk. Probiotics are living microorganisms and advise spacing probiotics at least 2 hours apart from antibiotics. And a probiotic that contains yeast. Saccharomyces, Clostridium Butyricum, and bacillus are not sensitive to antibiotics and can be used together with antibiotics.

Reference
1. 中华预防医学会微生态学分会儿科学组，益生菌儿科临床应用循证指南，中国实用儿科杂志 2017 年 2 月第32 卷第 2 期